Manchester United manager Erik ten Hag will look for a reaction from his team in a home match against Brentford in the Premier League.
United was overwhelmed in a 2-0 loss at Newcastle on Sunday and has dropped to fifth place, behind Newcastle and Tottenham on goal difference in the race for a top-four finish to qualify for the Champions League.
United has picked up just one point from its last three league games and is struggling without the suspended Casemiro in midfield. Third-place Newcastle visits West Ham, which climbed out of the relegation zone by beating Southampton on Sunday.
Barcelona needs a draw at home against Real Madrid to reach the Copa del Rey final for the first time since 2021.
It won the first leg 1-0 at the Santiago Bernabeu Stadium. A win would also make Xavi the first coach to lead Barcelona to four straight victories over Madrid since Pep Guardiola won five in a row from 2008-10.
Barcelona has never beaten its rival four consecutive times in the same season. The Catalan club is the Copa's most successful club with 31 trophies.
Madrid hasn't won it since 2014, when it beat Barcelona the last time it made it to the final.