Felix Mongo, a youth leader in Baringo County said Ruto's decision to dissolve the Cabinet marks a pivotal moment for the county.
Mongo wants the President appoint professionals instead of reinstating the former CSs.
"By bringing in experts from various fields, we can ensure that our government is driven by knowledge, experience, and a fresh perspective, it's time for a new era of leadership that prioritises competence and innovation for the betterment of our country," he said.
Kericho Catholic Diocese Bishop Alfred Rotich prayed for divine guidance as President Ruto navigates the political challenges ahead.
"Let us pray that the Holy Spirit may guide the President in this moment of discernment," Bishop Rotich said.
In the Mount Kenya region, politicians and residents of from Meru and Tharaka Nithi, home counties of former Agriculture CS Mithika Linturi his Interior counterpart Kithure Kindiki were shocked by the turn of events.
The MPs from the two counties that are collectively referred to as 'larger Meru' were hesitant to talk about the President's action.
"No, please. That is preemptive. Let me spare my thoughts for now," said an MP who sought anonymity.
But James Kithinji a resident of Maara, said the Head of State had done the unthinkable.
In North Rift, a section of leaders, farmers and residents described President Ruto's Cabinet as a 'let down' saying it failed to meet the expectations of Kenyans.
"The President has done well to dissolve his Cabinet. I support the move 100 per cent and it is my hope that he gets a new team to steer the country in the right direction, with less talk," Kesses MP Julius Rutto said.
Joseph Sang, a farmer in Uasin Gishu said qualified Kenyans should be allowed to apply for CS posts and be interviewed and picked on merit.
"There has been laxity in the Cabinet. As farmers, we were disappointed to see the distribution of substandard fertiliser through government agencies," said Sang.
In Kitale, some residents faulted the President for not sacking Prime Cabinet Secretary Mudavadi.
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They termed the dismissal of the Cabinet a bold move by the President and accused some of the former CSs of alleged corruption.
Justus Wanyonyi said CSs should be people of integrity.
"It is a bold move by the president. The Cabinet had failed the country," said Wanyonyi.
In Kakamega, Bishop Julius Abungana, Organising Secretary of the Federation of Indigenous Christian Churches of Kenya (FICCK) said Ruto's next pick should reflect budget cuts and national face to gain national acceptance.
"He should forget the reward of cronyism that landed him in a bad place and focus on people who can deliver, probably with the help of the church. I hope he will land on mature people who have the national and not personal interest at heart," he said.
Report by James Munyeki, Yvonne Chepkwony, Nikko Tanui, Kennedy Gachuhi, Clinton Ambujo, Anne Atieno, Willis Oketch, Renson Mnyamwezi, Titus Too, Osinde Obare, Martin Ndiema, Robert Amalemba and Edward Kosut