According to her Washington office, Jill's engagements will focus on empowering women and youth, addressing food insecurity, and promoting shared democratic values.
The visit follows the U.S.-Africa Leaders Summit late last year where she hosted a two-day spousal program.
This is Jill's sixth visit to Africa and third to Kenya.
A media dispatch indicate that after the State House meeting, the First Lady and her host will participate in a women's empowerment reception with U.S. Ambassador to Kenya Meg Whitman.
This event will be pooled press.
She will then have a rest before she engages in an entrepreneurship and sustainability event with a local company connecting tractor owners and farmers to highlight how young entrepreneurs are transforming agricultural practices in Kenya through technology, and improving livelihoods and food security.
"Afterwards, the First Lady will join First Lady Ruto to meet with local women as part of Mrs Ruto's Joyful Women initiative that promotes women's economic empowerment and financial inclusion," read part of the dispatch.
Later in the day, Jill Biden will attend a Shujaaz Konnect Festival, a local youth empowerment event in Nairobi, presented in collaboration with The MTV Staying Alive Foundation and spotlighting the U.S. government's support through the President's Emergency Plan for AIDS Relief (PEPFAR).
On Sunday morning, the First Lady will travel to visit a drought-affected area in Kenya to highlight the impacts of drought on communities before her departure later in the day.