Presidents Joe Biden (U.S) and Paul Kagame (Rwanda) will also address the Assembly on Wednesday.
Ruto left Kenya on Sunday to attend Queen Elizabeth II's funeral on Monday, September 19, in Westminster, United Kingdom, before heading to the United States for the UNGA conference.
He is accompanied by his wife Rachel Ruto, and a host of leaders including Foreign Affairs Chief Administrative Secretary Ababu Namwamba, Elgeyo Marakwet Senator Kipchumba Murkomen, and Kiharu MP Ndindi Nyoro.
Ruto also met Kenya's Permanent Representative to the UN, Amb Martin Kimani.
UNGA started on Tuesday, September 13, 2022, and is expected to end on Monday, September 27.