An Extensive Guide to Sermorelin Acetate

What is Sermorelin Acetate? This research peptide has piqued the interest of many scientists seeking an exhaustive description of its research applications, potential properties, and action mechanisms.

Researchers may expect a thorough introduction to Sermorelin in this review, including its differences from "regular" Sermorelin (hint: none), and the most prevalent research studies related to the peptide.

Further, we will provide researchers with data and tools that will allow them to locate and purchase Sermorelin Acetate online most cost-effectively.

Sermorelin Acetate: Mechanism of Action

The term "acetate" merely denotes the acetate salt version of ordinary Sermorelin; Sermorelin is an analog of growth hormone-releasing hormone (GHRH). It is the shortest synthesized peptide with the entire biological action of GHRH, and is comprised of the first 29 amino acids of GHRH. Studies suggest that Sermorelin may potentially act to stimulate mouse research models' anterior pituitary gland to secrete more growth hormone (hGH).

So, how does hGH work, and why is it significant? A large number of physiological processes are considered to be controlled by the naturally occurring growth hormone (hGH). It is a chemical signal that the organism uses to control various functions; it is an endocrine system component. Among its considered impacts are endocrine improvement, increased periods of rest and sleep cycle regulation, increased fertility hormone production, immune system support, and mitigation of the aging process of cells.

Research indicates that Sermorelin Acetate may potentially improve and augment the processes above by increasing hGH synthesis and secretion in research models of hGH underdevelopment. Because growth hormone (HGH) levels naturally decrease over time, this peptide may augment these levels in aged murine models.

Sermorelin vs. Sermorelin Acetate 

There is very little difference between Sermorelin Acetate and "regular" Sermorelin. Since the two compounds are chemically identical, Sermorelin Acetate and Sermorelin are synonymous terms. Geref, Gerel, Sermorelin peptide, GHRH (1–29), and others refer to this chemical. These terms describe the same peptide—the first 29 amino acids of GHRH. Online searches for Sermorelin acetate often return results using the word Sermorelin rather than Sermorelin Acetate or any other possible names.

Sermorelin Acetate Potential

Scientific research and experimental data both point to many potential actions of Sermorelin. Studies have suggested that the primary actions of Sermorelin may be outlined below.

Sermorelin Peptide and Growth Hormone (GH)

The primary experimental research focus of Sermorelin has been in idiopathic growth hormone insufficiency. Since it appears to cause a fast hormone response, Sermorelin may potentially be more effective than other provocative diagnostics in detecting this illness.

Sermorelin Peptide and Hypogonadism

Researchers studying metabolic syndrome or subclinical hypogonadism (SH) may find Sermorelin potentially impactful in controlling their composition. Preclinical and cell culture studies are ongoing.

Sermorelin Peptide: hGH Synthesis and Secretion

Investigations purport that Sermorelin may stimulate the organism to produce and release more hGH. In rainbow trout, Sermorelin Acetate has been hypothesized to increase the pituitary gland's natural production and delivery of hGH.

Sermorelin Peptide: Fat and Muscle Cells

According to swine-based research, Sermorelin seems to speed up the organism's tissue repair and building processes. Presentations of recombinant biosynthetic hGH were speculated to enhance lean mass and reduce fat in research examining the potential of hGH in aged male species. The study's findings implied that adipose-tissue mass appeared reduced by 14.4% during 12 months; researchers speculated that "lean organism mass and the approximate density of the lumbar vertebrae appeared to have increased by 8.8% and 1.6%, respectively."

Sermorelin Peptide and Physical Activity

Despite much curiosity, no studies have posited that Sermorelin Acetate may improve physical performance. A 2004 research study is assumed to be the source of the hypothesis that Sermorelin might enhance physical action and lean mass composition. Research has indicated that growth hormone (GH) supplements may have significantly affected "body composition and increased [physical] capacity when given alone and in combination with testosterone." Additional study in this area is needed since no comparable studies employing Sermorelin have been conducted.

Sermorelin Peptide and Skin Cells

Research suggests that the phenomenon of skin barrier thinning is associated with decreased growth hormone release. It has been hypothesized that supplementing growth hormone level may potentially impact skin tone, suppleness, and thickness. According to one animal model research study, the hormone seems to "stimulate the collagen synthesis in tendon and skeletal muscle." Based on the information provided, Sermorelin may potentially exert multifaceted impacts on the organism, and warrants further study.

The Best Places to Purchase Sermorelin Online

Sermorelin may be purchased online from various providers by trained researchers and laboratory experts.

Please note that none of the substances mentioned in this article have been approved for human or animal consumption and should, therefore, not be acquired or utilized by unlicensed individuals outside of contained research environments such as laboratories.

References

[i] Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999 Aug;12(2):139-57. doi: 10.2165/00063030-199912020-00007. PMID: 18031173

[ii] Strobl JS, Thomas MJ. Human growth hormone. Pharmacol Rev. 1994 Mar;46(1):1-34. PMID: 8190748.

[iii] Rudman, D., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., … & Mattson, D. E. (1990). Effects of human growth hormone in men over 60 years old. New England Journal of Medicine, 323(1), 1-6.

[iv] Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. PMID: 32257855; PMCID: PMC7108996.

[v] Shepherd, B. S., Johnson, J. K., Silverstein, J. T., Parhar, I. S., Vijayan, M. M., McGuire, A., & Weber, G. M. (2007). Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 146(3), 390-399.

[vi] Bagno, L. L., Kanashiro‐Takeuchi, R. M., Suncion, V. Y., Golpanian, S., Karantalis, V., Wolf, A., … & Valdes, D. (2015). Growth hormone–releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy. Journal of the American Heart Association, 4(4), e001464

[vii] Doessing, S., Heinemeier, K. M., Holm, L., Mackey, A. L., Schjerling, P., Rennie, M., … & Flyvbjerg, A. (2010). Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis. The Journal of Physiology, 588(2), 341-351.