In boys' final, Dagoretti High School shocked defending champions Highway Secondary School 1-0.
Dismas Ongocho scored the lone goal as Dagoretti dethroned Highway who are set for World School Games in Morocco next month.
In rugby Sevens, Upper Hill cruised 14-10 past Lenana to win the title. Both teams will represent the region at the national games.
In volleyball, Ruthimitu Mixed and Soweto emerged champions in boys and girls respectively.
Ruthimitu Mixed saw off Hospital Hill 3-1 while Soweto spiked Brown Hill 3-0.
St Dorcas went home with the netball title after narrowly edging out Mbagathi 26-25.
Meanwhile, Moses Mbora, who is the executive secretary, Kuppet, Nairobi branch, presented winners with trophies, urging them to make the region proud at the national finals in Kakamega.