It is the biggest attack on the airport in Haiti's history. Toussaint Louverture International Airport was closed when the attack occurred, with no planes operating and no passengers on site.
Last week, the airport was struck briefly by bullets amid ongoing gang attacks but gangs did not enter the airport or seize control of it.
The latest surge in violence began Thursday as Prime Minister Ariel Henry travelled to Kenya to sign a deal for the U.N.-backed deployment of 1,000 Kenyan police officers to help fight the gangs.
Gang leader Jimmy Cherizier - who goes by the nickname "Barbecue" - issued a video statement saying a coordinated attack by armed groups was underway to oust Prime Minister Henry. He said the groups were seeking to get the prime minister to resign and "free the country." He said they would "use all strategies to achieve that goal."
At a State Department news briefing Monday, spokesman Matt Miller said the United States condemned the violence and is closely monitoring the situation. He said many of those responsible for the uptick in violence have been designated by the U.S. government for sanction for violations of human rights and illicit drugs.
He urged the U.N. to finalize "the Multinational Security Support Mission to assist the Haiti National Police in dealing with the dire security situation on the ground."
Miller said it was the understanding of the State Department Prime Minister Henry would be returning to Haiti, but deferred to the Haitian government regarding when that might be and where he has been since he left Kenya last week.
Henry became Haiti's leader after the 2021 assassination of President Jovenel Moise, plunging the country into extraordinary levels of violence and chaos. He has twice promised to hold new elections but has reneged each time.