Holders Chelsea eased into the fourth round with a 4-1 win over third tier Walsall, while Southampton thrashed second tier Milton Keynes Dons 6-0 with two goals each for Jay Rodriguez, Sadio Mane and Shane Long.
Newcastle United's dismal start to the season continued as they were beaten 1-0 at home by second division Sheffield Wednesday, while Manchester United made light work of Ipswich Town, winning 3-0 at Old Trafford.